When Hypno-Germs invade Shake's brain, they force him to do a number of insane things. Frylock uses Mexican jumping-beans to combat the germs in Shakes head with a theatrical spectacular, until the beans kill all of them.
Their only interest is mind control... and creating outlandish off-Broadway plays, after drinking on the weekends.
This is the first episode to use "asshole" uncensored. It got censored for the last time in Dirtfoot.
This is the last episode where Carl is absent until The Marines.
Carl is not visibly seen in this episode, but he can be heard yelling "Jackass!" as he drives past Shake.