The Mother Clam is a character that appears in the episode "The Last One Forever and Ever (For Real This Time) (We Fucking Mean It)." She is a large shellfish with a purple shell, containing a tongue and a jewel inside. The clam also has gigantic lips and can crush an enemy just by snapping its jaws shut.
In the episode, "The Last One Forever and Ever (For Real This Time) (We Fucking Mean It)," Frylock needs the jewel which is contained inside the Mother Clam to stay alive, as his diamond is dying out, causing him to die. Eventually, Frylock becomes too weak to obtain the diamond and sends Master Shake and Meatwad to retrieve the jewel. After Master Shake is killed by the French-speaking shellfish, Meatwad grabs the diamond from the Mother Clam, as she becomes angered, sending the shellfish after him. Though, Meatwad uses laser from the jewel to destroy and kill the Mother Clam and her shellfish minions.