Master Shake suffers from high blood pressure, and ends up in the hospital. After this, he promises to get fit. When walking by Carl's house, Carl tells him about a energy drink he is distributing that will get Shake buff without doing anything.
As he returns home, Shake shows off his new strength by tossing an exercising Meatwad, along with Frylock's treadmill, through a wall. Shake attempts to provoke Frylock into a physical altercation as he floats away and avoids confrontation, emphasizing his new testosterone-driven hotheaded attitude.
After he falls asleep, his muscles come to life. Shake's muscles heads to a local bar, where it kills dozens of people. The next morning, Frylock alarms Shake about the events from the night before, but Shake is unaware of what happened until his muscles come back to life, threatening Frylock and Shake if they do not get more of Carl's energy drink.
Upon arriving at Carl's house, Shake's muscles begin to break everything that he owns until he gives him his energy drinks. Frylock arrives and gives Shake's muscles a muscle relaxant, which sedates his body below the mouth. Frylock then takes Shake to a veal fattening pen to melt away the muscles.
Six months later, Carl drives Frylock and Meatwad to check on Shake, who has become extremely obese and can only communicate through moos. He warns them to close the gate since there are coyotes nearby, but they cannot understand him. Frylock and Meatwad then watch sadly as Shake is eaten alive while Carl begins to close his car windows, telling them to "get in the car".
- Shake's Muscles are killed after Shake gets too fat.
- Master Shake is eaten by coyotes.
- The cover image for the digital downloads for the tenth season was derived from this episode.
- Carl telling Shake that "He's just gonna die" is a reference to the episode "Diet", in which the same thing is said to Meatwad.
- This marks the third time Meatwad wears his jogging attire.
- This episode's plot of Shake ingesting a Singapore drink called Thump was confirmed alongside "Piranha Germs" and "Spacecadeuce" when "Totem Pole" premiered.